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Ayessa G. Ibañez posted an update in the group MT 30 – IJ (LEC) 3 years, 7 months ago

Histology plays a crucial role in the field of medicine. Histological examinations are performed to identify and diagnose many pathological diseases. Aside from determining the severity of the disease and issuing a prognosis, histology can also determine other diseases one can get from certain health conditions.

In a journal article by Hagiwara et al. (2020), the researchers did endomyocardial biopsies in hemodialysis (HD) patients. Hemodialysis is an advanced treatment for kidney failure. Patients undergoing hemodialysis have a higher risk of acquiring cardiovascular diseases, most especially heart failure. The cardiac histological findings from HD patients enabled them to identify similar biological responses from having cardiomyopathy. The findings include myocyte hypertrophy and interstitial fibrosis. Although cardiomyopathy-associated with HD and cardiomyopathy have similar biological responses to cardiomyopathy, there are still differences in their histological features. As the authors stated, they are “histologically indistinguishable.”

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https://www.sciencedirect.com/science/article/pii/S1054880720300600

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- Ayessa G. Ibañez replied 3 years, 7 months ago
  
  With their study, we can see how histology aids in identifying patients’ health conditions and, at the same time, distinguishing their underlying diseases. The latter is also important in medicine as failure to identify and treat them accordingly could worsen the patient’s overall state.
  
  If you are interested in the study mentioned, you can access it here:
  Hagiwara et al. (2020). Histological features of endomyocardial biopsies in patients undergoing hemodialysis: Comparison with dilated cardiomyopathy and hypertensive heart disease. https://doi.org/10.1016/j.carpath.2020.107256. Retrieved from https://www.sciencedirect.com/science/article/pii/S1054880720300600
- Ayessa G. Ibañez replied 3 years, 7 months ago
  Another aid of histology in the science of medicine is that it can be used to provide a more accurate basis and references for preventing some health conditions.
  
  In a research article authored by Chen et al. (2022), they seek to determine a more accurate basis and reference for the secondary prevention of large atherosclerotic and cardiogenic embolic thrombus, which are two subtypes of stroke, through histology.
  - Ayessa G. Ibañez replied 3 years, 7 months ago
    The former, atherosclerosis, is the hardening of arteries caused by gradual plaque buildup. Over time, this can completely block the blood flow onto your brain. The latter, cardiogenic embolic, causes blood clots or embolus, which can form and break off from the heart. The clot travels through the bloodstream and blocks the flow of oxygen-rich blood as it lodges in the brain’s artery. The lack of oxygen due to atherosclerosis and cardiogenic embolic causes damage, destruction, or even tissue death of the brain, leading to stroke.
    - Ayessa G. Ibañez replied 3 years, 7 months ago
      
      Through histological analysis, the researchers examined the thrombi of the two subtypes mentioned (you may access the research article to see the histology results of the study). They found out that there is no histological distinction between the thrombi of large atherosclerotic and cardiogenic embolic. Their RBCs or fibrin/platelets content has no difference. Based on their findings, they presented strategies for preventing stroke recurrences, including platelet therapy and anticoagulation treatments.
      
      The perspective of histology is broad. The research articles presented here are only about the circulatory system, but we can see how histology has already traversed complex aspects.
      
      If you are interested in the study mentioned, you can access it here:
      Chen et al. (2022). No Histological Difference between Large Atherosclerotic and Cardiogenic Embolic Thrombus. http://dx.doi.org/10.1155/2022/4845264
      Retrieved from https://www.researchgate.net/publication/359027079_No_Histological_Difference_between_Large_Atherosclerotic_and_Cardiogenic_Embolic_Thrombus

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