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Ryeza Dayola posted an update in the group
MT 30 – IJ (LEC) 3 years, 11 months ago Continuous-flow (CF) ventricular assist devices (VAD) are an established option for treatment of end-stage heart failure. However, the effect of long-term CF with lack of peripheral arterial wall motions on blood pressure regulation and end-organ arterial wall sclerosis, especially in the case of long-term support, remains unclear. In this article by Potapov, Dranishnikov, Morawietz, et al., tissue samples obtained at autopsy from liver, kidney, coronary arteries, and brain from 27 VAD recipients supported for >180 days between 2000 and 2010 were histologically examined.
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Between 2000 and 2010, tissue samples from the liver, kidney, coronary arteries, and brain of 27 VAD recipients who had been on the device for more than 180 days were histologically examined to assess vascular changes such as perivascular infiltrate, intravascular infiltrate, wall thickness, thrombosis, endothelial cell swelling, vessel wall necrosis, and perivascular fibrosis. -
According to Potapov, Dranishnikov, Morawietz, et al., all of the tissue samples were collected for diagnostic purposes only, not for research, and were fixed in 4% buffered formalin for 1 or 2 days following surgery or autopsy, respectively, before being embedded in paraffin. All of the available arteries and arterioles on tissue sections in each organ were inspected and analyzed for any modifications caused by a cardiac assist device.
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Before and after surgery, demographic and clinical data were similar. There were no significant variations in artery wall features between the two groups, according to histologic examinations. They came to the conclusion that long-term mechanical circulatory support with CF devices has no negative impact on end-organ vasculature artery wall characteristics.
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Because histology is a discipline of human anatomy that deals with the microscopic examination of tissues in the human body, it is particularly valuable in the identification of certain disorders. In the human body, there is a level of organization. As a result, understanding the exact structure and function of the organ system requires a thorough understanding of histology. Biological tissue samples taken from patients can be researched in depth to help medical experts learn more about the patient’s condition, possibly comprehend its causes, and provide therapy or management recommendations.
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