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Rosemarie C. Abraham posted an update in the group MT 30 – IJ (LEC) 3 years, 7 months ago

The journal article that caught my attention was written by Maksymilian Onyszkiewicz, Kinga Jaworska, and Marcin Ufnal. It was mentioned in the journal that there is
numerous evidence suggesting that products derived from gut flora affect cardiovascular function. For example, short-chain fatty acids, the product of bacterial fermentation of fibre, have been shown to dilate blood vessels and lower blood pressure.

This paper reviews studies on the cardiovascular effects of microbiota-produced short-chain fatty acids and methylamines.

Short chain fatty acids and methylamines produced by gut microbiota as mediators and markers in the circulatory system – PMC

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016413/

Ample evidence suggests that gut microbiota-derived products affect the circulatory system functions. For instance, short chain fatty acids, that are the products of dietary fiber bacterial fermentation, have been found to dilate blood vessels and lower …
- Rosemarie C. Abraham replied 3 years, 7 months ago
  According to the three authors, although there are advances in the diagnosis and treatment of cardiovascular disease, we cannot deny the fact that there are still major gaps when it comes to such complications in terms of understanding the mechanisms in the underlying cardiovascular system conditions especially that there is evidence that persuades that such certain gut microbiota products like short-chain fatty acids and methylamines can damage our circulatory system.
  - Rosemarie C. Abraham replied 3 years, 7 months ago
    They also provided lots of information for example they emphasize what was gut bacteria doing in human homeostasis. It is clearly stated in the journal article that bacteria and fungi settle in the intestines and skin of mammals early after birth. In terms of data, the number of gut bacteria is at least the same as the number of human cells, where at the same time, the composition of the human microflora is unique for each person. Additionally, they also provided significant factors that will identify the composition of the gut microbiota and these factors include geography, age, diet, mode of delivery, and postnatal nutrition.
    - Rosemarie C. Abraham replied 3 years, 7 months ago
      
      I am also overwhelmed to be able to absorb lots of information, especially regarding the idea that vaginal delivery and breastfeeding have been shown to be more associated with more diverse microorganisms than cesarean section.
      
      They also named the most common bacterial strains found in the human gut which include Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria.
      
      Rosemarie C. Abraham replied 3 years, 7 months ago
      
      The underlying mechanism of the interaction between the gut flora and the circulatory system is unclear. However, accumulating experimental data shows that at least two potential pathways are possible.
      
      First, products derived from the gut microbiota can stimulate the afferent (sensory) nerves of the enteric nervous system and regulate the cardiovascular centre of the brain. The latter affects the activity of the autonomic nervous system. The autonomic nervous system controls the function of the heart, vascular system, and glands that release cardiovascular hormones.
      
      Second, the products of the intestinal flora can enter the bloodstream, thereby affecting the function of organs and tissues that contribute to the homeostasis of the circulatory system. Since most of the intestinal-derived molecules first pass through the liver, the systemic effects of microbiota products may also depend on liver metabolites.
      
      Ps. to know more please click the link —> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016413/
      
      Rosemarie C. Abraham replied 3 years, 7 months ago
      
      The authors concluded that indeed products produced in the gut flora really affect cardiovascular function. The benefits and its toxic effects were also described as well as giving an explanation of how short-chain fatty acids lower blood pressure. Also, the negative effects of trimethylamine which triggers the rise of the blood pressure and its adverse effects on the circulatory system.
      
      Histologically speaking, I believe that it is really necessary that we know the histology of the circulatory system in terms of its structure and function so that we can easily understand the mechanism, identify the disorders, and the possible diagnosis. Also, understanding the histological background of the circulatory system also helps medical experts in handling or managing the disease.
      
      I am really thankful that I was given the opportunity to read this journal article. Although I know this topic regarding the circulatory system is very broad I hope you will be able to learn much just as I do.

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