This article has a growing body of data shows that gut bacteria play a role in the maintenance of the circulatory system’s homeostasis. More and more research indicates that human homeostasis is highly dependent on the existence of a mutualistic interaction with gut bacteria, and fecal transplantation has lately emerged as a viable treatment option for several intestinal disorders that are life-threatening. It has been shown that metabolic and cardiovascular disorders, particularly hypertension, are connected with dysbiosis of the gut microbiota, and some research indicates that fecal transplantation may potentially be a therapeutic target in the treatment of cardiovascular and metabolic diseases. The research on the regulatory role of hydrogen sulfide (H2S) in the circulatory system has so far concentrated primarily on the effects of H2S produced by enzymes in the heart, kidneys, vasculature, or brain, with little attention paid to the hemodynamic effects of H2S derived from gut bacteria or other sources. H2S generated by the gut microbiota has only been studied in the gastrointestinal tract, and its biological impact has only been studied locally. Gut bacteria have the potential to influence the control of the circulatory system via at least two mechanisms. In the first instance, gut bacteria and/or their metabolites may cause the enteric nervous system to be stimulated. afferent sensory fibers are used to communicate with the brain in the case of the latter. A signal of this kind may have an effect on the activity of brain areas that are involved in the regulation of the circulatory system. This pattern of communication between the stomach and the brain has already been described in the context of cytokines. Second, gut bacteria and their metabolites have the potential to enter the circulation and impact the function of organs and tissues that are critical in maintaining the homeostasis of the circulatory system. This intricate multilayer structure, which inhibits the free flow of substances between the gut lumen and circulation, is responsible for preventing the entry of gut-derived molecules into the bloodstream (also known as the gut-blood barrier (GBB)).

Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis – PMC

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273628/

Accumulating evidence suggests that gut bacteria play a role in homeostasis of the circulatory system in mammals. First, gut bacteria may affect the nervous control of the circulatory system via the sensory fibres of the enteric nervous system. Second, …