Sulawesi medaka’s circulatory system, particularly the heart and bulbus anteriosus, is similar to that of zebrafish, however, there are some changes in the anatomy of the circulatory system and other elements comparable to other Teleostei fish. These findings show that Sulawesi medaka fish can be utilised as models, particularly in cardiovascular studies, such as cardiovascular development and cardiovascular illness in people and animals.

It was said in the article or to further understand the Medaka fish (Oryzias sp.) or “rice fish” is a non-consumption fish or decorative fish endemic to Asia. The medaka fish, on the other hand, is one of the most well-known animal models and is frequently utilised by researchers worldwide for studies in numerous sectors of science, including biology and medicine, as have Zebrafish that have been produced as animal models. Medaka fish were introduced as model animals for Parkinson’s disease research caused by environmental pollution and genetic causes. Several mutant medaka fish have also been created for medication testing for diabetes, cancer, and other degenerative disorders.

In the article using the Medaka Fish is used for the experiment in relation to the histology of the circulatory system and it was also discuss in the article about the use of the Zebrafish as a novel disease model for cardiac hyperthropy and other heart failure, it was suggested that Sulawesi medaka fish can also be used as cardiac disease model especially in the use of fish as animal models in research of cardiovascular disease.

Source: https://www.researchgate.net/publication/325749183_Histological_study_of_the_circulatory_system_of_Sulawesi_Medaka_fish_Oryzias_celebensis_for_animal_model_research