• Silliman University Cafeteria – The second oldest food establishment in Dumaguete City, famous for its locally made cheese bread using ingredients from the Silliman Farm.

• Villareal Hall – Named after Cornelio Villareal, a Silliman alumnus and former Speaker of the House of Representatives of the Philippines. It houses the College of Law.

• Science Complex – Home to the Biology, Chemistry, Physics, and Mathematics Departments, formerly known as the Education building and named after Dr. Clyde Heflin, a pioneering educator in the Philippines.

• Oriental Hall – Originally a girls’ dormitory in 1920, later housing the College of Business Administration for 30 years.

• Silliman University Church – Constructed from 1941 to 1949, featuring beautiful stained glass windows and an amphitheatre used for various events.

• Hibbard Hall – Built in 1932, used as the College of Business Administration and now houses the Ethno-Anthro Museum.

• Katipunan Hall – Constructed in 1916 as a Mission Hospital administered by the Langheim couple.

• College of Business Administration – Built in 2003 with Level IV accreditation from PAASCU.

• Arts and Sciences Building (Luz Ausejo Hall) – Inaugurated in 1998.

• Alice Fullerton Hall – Previously used as a dormitory and now serves the graduate school.

• Ethel Chapman – Utilized by ICLS and formerly a dormitory.

• Mary Marquis-Smith Hall, Olivia Villaflores-Yanson Hall, Barry Thompson Learning Resource Center – Used by the College of Nursing.

• Roble Hall – Utilized by the Senior High School.

• Claire Isabel McGill Luce Auditorium – Built in 1974, a 761-seat cultural center made possible by the Henry Luce Foundation.

• Silliman University Library – Established in 1978 with a vast collection of books, partly funded by USAID, and recognized as an Outstanding Library by PAARL.

• Silliman Gym – Built using dismantled airplane hangar parts and situated next to the Shaw Memorial Pool and Ravello field.

• Chapel of Evangel – Constructed in 1957, Constructed in 1957, originally home to the Silliman Bible School.

• Angelo King and Allied Medical Sciences Center – A 10.4 million edifice donated by Angelo King and inaugurated in 1996.

• Silliman School of Medicine – Inaugurated in 2013.

• Dr. Romeo Ariniego Art Gallery – Donated by Dr. Romeo P. Ariniego, inaugurated in 2017.

• Uytengsu Hall – Donated by the Uytengsu Family in memory of their son who had his pre-law program in SU.

• Guy Hall – Built in 1918 as a boys’ dormitory and now houses offices on the first floor and classrooms on the second.

• Leopoldo Ruiz Hall – The administration building hosting various university offices.

• Silliman Hall – The oldest building, constructed in 1903 and currently used for lectures, conferences, and events, with the Department of Fine Arts on the second floor.