1.The Silliman Church, inaugurated in 1949 but intended for completion in 1942, serves as a significant venue for services and events, featuring an amphitheater.
2.Silliman Hall, the oldest building since 1903, originally served various purposes like classrooms and dorms. Presently used for lectures, events, and houses the Fine Arts department.
3.Oriental Hall, initially a girls’ dorm in 1920, later transformed into the College of Business Administration until 2003.
4.Hibbard Hall, constructed in 1942, now houses the Ethno-Anthro Museum displaying Luzon, Visayas, and Mindanao artifacts.
5.Claire Isabel McGill-Luce Auditorium, built in 1974, accommodates 761 individuals and hosts diverse cultural events.
6.SU Library, established in 1978, stands as one of Asia’s largest libraries housing over 250,000 volumes.
7.College of Business and Administration, accredited by PAASCU at Level IV, established in 2003.
8.SU Gymnasium, built using parts of an airplane hangar, is adjacent to Shaw Memorial Pool and Ravello field.
9.School of Medicine classes began in 2005-2006 with 11 students, using a unique Problem-Based Learning Curriculum.
10.Ravello Field, an outdoor sports field beside the SU Gymnasium and Shaw Memorial Pool.
11.Uytengsu Hall, donated for pre-law studies and presently used for various purposes.
12.Ausejo Hall, established in 1988, serves as an Art and Science building.
13.Angelo King and Allied Medical Sciences Center, donated by Angelo King, houses ICLS and IRS.
14.Guy Hall, constructed in 1918 and presently accommodates offices and classrooms.
15.Olivia Villaflores-Yanson Hall, utilized by the College of Nursing.
16.Dr. Romeo Ariniego Art Gallery, inaugurated in 2017, donated by Dr. Romeo P. Ariniego.
17.Alice Fullerton Hall, used by the graduate school and previously a dormitory.
18.SU Cafeteria, renowned for locally sourced cheese bread from Silliman Farm.
19.Leopoldo Ruiz Hall, houses various administrative offices.
20.Katipunan Hall, previously served as a Mission Hospital.
21.Villareal Hall, home to the College of Law, named after Cornelio Villareal, an esteemed alumnus and former Speaker of the House of Representatives.
22.Chapel of Evangel, once the residence of the Silliman Bible School.
23.Uytengsu Foundation Computer Studies Hall, accommodates the College of Computer Sciences.
25.Roble Hall, utilized by the Senior High School.
26.Ethel Chapman – The Ethel Chapman building is used by ICLS and was once a dormitory
27.Science Complex – This structure currently houses the Biology, Chemistry, Physics and Mathematics Departments. It was formerly known as the Education building and it is also named after Dr. Clyde Heflin.