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Julianne Mae Salvoro posted an update in the group MT 30 – GH (Lec) 3 years, 7 months ago

Hi guys! Here’s the article I stumbled upon while doing my research. Take time to read this and I hope y’all find it enlightening!

Arterial wall histology in chronic pulsatile-flow and continuous-flow device circulatory support – PubMed

https://pubmed.ncbi.nlm.nih.gov/22995552/

Long-term mechanical circulatory support with CF devices does not adversely influence arterial wall properties of the end-organ vasculature.
- Julianne Mae Salvoro replied 3 years, 7 months ago
  Taking into consideration the histology of the circulatory system, the arterial wall was the primary focus of this article. Arteries are tubular collections of cells that transmit oxygenated blood and nutrients from the heart to the body’s tissues. Blood flows through the arteries in sequence of decreasing luminal diameter, beginning with the biggest artery (the aorta) and ending with the smallest arterioles. The article stated that continuous-flow (CF) ventricular assist devices (VAD) have been used for a long time to treat heart failure that has reached its last stage. But it’s still unclear what happens when someone has CF for a long time, and their arterial walls don’t move. Hence, the researchers obtained tissue samples and histologically examined them to evaluate vascular changes, which include perivascular infiltrate, intravascular infiltrate, wall thickness, thrombosis, endothelial cell swelling, vessel wall necrosis, and perivascular fibrosis. Then pulsatile-flow (PF) devices were implanted in 9 patients, whereas continuous-flow (CF) devices were implanted in 16. However, Potapov et al. were unable to discover any significant differences in arterial wall features across these patient groups. They determined that long-term mechanical circulatory support using continuous-flow devices had no negative effect on the arterial wall characteristics of the end-organ vasculature.
  
  Overall, the article and all other studies demonstrate how beneficial it is to examine the histological properties of an organ. It aids in the discovery of new information by making it more accessible. Indeed, the article is interesting and will undoubtedly help us to have a better grasp of the subject matter.
  
  Reference:
  Potapov, E. V., Dranishnikov, N., Morawietz, L., Stepanenko, A., Rezai, S., Blechschmidt, C., Lehmkuhl, H. B., Weng, Y., Pasic, M., Hübler, M., Hetzer, R., & Krabatsch, T. (2012). Arterial wall histology in chronic pulsatile-flow and continuous-flow device circulatory support. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 31(11), 1171–1176. https://doi.org/10.1016/j.healun.2012.08.013

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