Below are the ten histological illustrations of the different body tissues that I made.
Here\’s the link to the pictures uploaded for better viewing.
In the Philippines, heart diseases belong to the top ten leading causes of morbidity. The World Health Organization (WHO) also reported ischemic heart disease as the number one cause of death worldwide as of 2019. Thus, it is safe to say that heart diseases are indeed the world’s greatest killer.
This information is especially concerning as the heart has limited regenerative capacity. Ischemia and other factors can damage your cardiomyocytes, which are the cells that generate contractile force in your heart. Residual viable cardiomyocytes have a limited ability to proliferate, and noncontractile fibrous tissue replaces dead cardiomyocytes. Since it is noncontractile, there would be changes in the pumping mechanism of your heart. It causes functional degeneration and the onset of heart failure.
The article below contains research addressing heart diseases. It presents information about heart regeneration using pluripotent stem cells (PSCs). Any advancement in this research may be the answer to the world’s greatest killer.
The article reviewed the status of the various researches related to the topic. As of basic knowledge, PSCs or pluripotent stem cells are excellent sources for regenerative medicine because of their infinite availability and scalability. They are present in umbilical cord blood and other tissues. It may be why infants show functional recovery for severe myocardial infarction better than adults.
As per the researchers’ preclinical studies, there were two ways to deliver human PSC-derived cardiomyocytes (hPSC-CMs) to animal models. Both had advantages and disadvantages that were weighed and resolved to make better analyses in preparation for clinical studies.
During the clinical studies, the six patients did not manifest any complications, but the efficacy of the study was not examined. Different studies worldwide soon launched their phase 1 clinical studies for the hPSCs. However, there were complications with the procedure, such as poor engraftment, immune rejection, and post-transplant arrhythmia.
Nevertheless, with the technology we have today, there is no knowing when researchers will provide better reports for heart regeneration. This type of study must be continued as any advancements can cause significant changes to the treatment of heart diseases.
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