Activity

  • Richmond Zent A. Fulache posted an update in the group Group logo of MT30-Histology Art ABMT30-Histology Art AB 4 years, 1 month ago

    • Adult Human Dermal Progenitor Cell Transplantation Modulates the Functional Outcome of Split-Thickness Skin Xenografts
      • Following full-thickness skin injuries, epithelialization of the wound is essential. The standard of care to achieve this wound “closure” in patients is autologous split-thickness skin grafting (STSG). However, patients living with STSGs report significant chronic impairments leading to functional deficiencies such as itch, altered sensation, fragility, hypertrophic scarring, and contractures. These features are attributable to the absence of functional dermis combined with the formation of disorganized fibrotic extracellular matrix. Recent work has demonstrated the existence of dermal progenitor cells (DPCs) residing within hair follicles that function to continuously regenerate mesenchymal tissue. The present work examines whether cultured DPCs could regenerate dermis within an STSG and improve overall graft function. Adult human DPCs were transplanted into a full-thickness skin wound in immune-compromised mice and closed with a human STSG. At 3 months, human DPCs (hDPCs) had successfully integrated into the xenograft and differentiated into various regionally specified phenotypes, improving both viscoelastic properties of the graft and mitigating pruritus.
        • This kind of out-of-the-box thinking has been truly baffling from the past years. Xenograft is using animal tissues as a temporary replacement for human tissues. It has been used extensively for victims that has third-degree burn and also for cancer. Humankind has been truly using all kinds of resources and manners of preservation. Imagine, for those patients who have extensive burn, whose body are covered with a lot of burnt tissue, animal tissue can be used as an temporary replacement for healing. The research study that I have taken reference to is a great study that examines whether xenografts affect the overall graft function.

          We wouldn’t have been able to do this if it weren’t for the advancements of medical research and technology. This research could potentially make xenografts an acceptable surgery towards those people with different views and in return save more lives.

        you're currently offline

        0

        New Report

        Close