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MT 30 – GH (Lec) 4 years, 1 month ago 
Long-term spaceflight and the cardiovascular system – PMCWhile early investigations into the physiological effects of spaceflight suggest the body’s ability to reversibly adapt, the corresponding effects of long-term spaceflight (>6 months) are much less conclusive. Prolonged exposure to microgravity …
According to the researchers, long-term exposure to microgravity and radiation has significant impacts on the cardiovascular system, including substantial cephalad fluid transfer and changed arterial pressure, both of which weaken the blood pressure regulating mechanisms and increase cardiac output. Aside from that, the absence of venous compression lowers central venous pressure.
There was a report that during the Apollo era (1961-1972), astronaut James Benson Irwan experienced premature ventricular contractions related to hypokalemia during the Apollo 15 mission. That is why, the other concern of NASA about long-term spaceflight is the possibility of cardiac arrhythmias, or abnormalities in the regular sequence of the electrical impulses necessary for coordinated atrial and ventricular contraction.
Overall, more investigations or study into the effects of long-term spaceflight, such as epigenetic and genetic changes caused by radiation, stress, or microgravity, is needed to fully inform NASA and other groups on how to develop preventative countermeasures against the potential harms that exploratory travel might cause to an astronaut bound for any planet beyond our own.
Reference:
Vernice, N. A., Meydan, C., Afshinnekoo, E., & Mason, C. E. (2020). Long-term spaceflight and the cardiovascular system. Precision Clinical Medicine, 3(4), 284–291. https://doi.org/10.1093/pcmedi/pbaa022