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Princess Maranda posted an update in the group
MT 30 – IJ (LEC) 4 years, 1 month ago This article by Osadchii (2015) highlights the emerging role of neurotensin (NT) in the regulation of the processes of the cardiovascular system and its broad effect on heart rate, systemic flow and blood pressure.
Neurotensin (NT), a tridecapeptide discovered in the bovine hypothalamus, appears to be playing an increasingly important role in cardiovascular regulation. Acute circulatory disorders may be caused by elevated systemic levels of NT, which may also predict cardiovascular morbidity and mortality in population studies.
Emerging role of neurotensin in regulation of the cardiovascular system – PubMedThere is increasing evidence in support of an important role played by neurotensin (NT), a tridecapeptide originally found in bovine hypothalamus, in regulation of cardiovascular system. Elevated systemic levels of NT may contribute to pathogenesis of acute circulatory disoders, and predict the risk …
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This increase was not easily subdued by common antagonists, indicating that the NT has a direct effect on the pacemaker (sinoatrial node).
Further research reveals that NT is mediated by the release of adrenal catecholamines. This is supported by the increased adrenaline levels in the laboratory animals.