Ok, hear this out! Adipose Tissue is now recognized as a critical regulator of cardiovascular health. It is mediated through the secretion of a variety of bioactive molecules, including adipocytokines, microvesicles, and gaseous messengers, all of which have a variety of endocrine and paracrine effects on the circulatory system.

Complex homeostatic mechanisms and local cell-cell interactions regulate adipose tissue function and secretome, which can be disrupted by obesity. Speaking of Obesity, there has been a recent study about Obesity and its relationship with Adipose Tissue and Cardiovascular Health. Obesity, the most frequent dietary problem in developed countries, is linked to an elevated risk of cardiovascular death and morbidity. However, the biological basis for the relationship between obesity and cardiovascular problems is still unknown. Recent advancements in adipose tissue biology suggest that it is not only an energy storage organ, but also a secretory organ, releasing a number of bioactive chemicals such as leptin and adiponectin that may alter circulatory system function and structural integrity.

With the broad distribution of functional receptors in vascular cells, leptin may play a major role in regulating vascular tone, in addition to being a satiety signal for the central nervous system and being linked to insulin and glucose metabolism. Adiponectin, a more recently identified protein, appears to serve a protective function in experimental models of vascular damage, most likely due to its capacity to block monocyte adhesion to endothelial cells, an early step in the atherosclerotic process. There is already substantial evidence associating altered adipocyte hormone production with obesity-related cardiovascular problems.

Adipose tissue as an endocrine organ: role of leptin and adiponectin in the pathogenesis of cardiovascular diseases – PubMed

https://pubmed.ncbi.nlm.nih.gov/12903905/

Obesity, the most common nutritional disorder in industrial countries, is associated with increased cardiovascular mortality and morbidity. Nevertheless, the molecular basis linking obesity with cardiovascular disturbances have not yet been fully clarified. Recent advances in the biology of adipose …