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  • Angelyn Evan Bomediano posted an update in the group Group logo of MT 30 - GH (Lec)MT 30 – GH (Lec) 1 year, 11 months ago

    Hello everyone, Good Evening! I hope y’all are doing great. I would just like to share this article I read about “Human blood vessel organoids as a model of diabetic vasculopathy”. This text contains reports on the formation of three-dimensional self-organizing human blood artery organoids from pluripotent stem cells. According to IDF Diabetes Atlas (2021), there are 537 million adults who are living with Diabetes. Sadly, with this known statistics, my family are one of which. With that being said, I am highly encouraging you all to take time in reading this article as this disease is one of the commonly neglected yet prevalent and dangerous one. Remember also that awareness is always better than treatments.

    • The prevalence of diabetes is now a global epidemic and it has been the leading cause of blindness, kidney failure, heart attack, stroke and amputation of the lower extremities. These are sometimes caused by changes in blood vessels such as expansion of the basement membrane and loss of vascular cells and on the other hand, it also impairs the function of endothelial cells and interferes with communication between endothelial cells and pericytes. On this text, development of self-assembled three-dimensional human vascular organoids from pluripotent stem cells will be reported. The organoids of human blood vessels contain endothelial cells and pericytes, which self-assemble into the capillary network surrounded by the basement membrane. Human vascular organoids transplanted into mice form stable perfused vascular trees such as arteries, arterioles and venules. In vitro exposure of vascular organoids to hyperglycemia and inflammatory cytokines causes thickening of the vascular basement membrane. Human blood vessels exposed in vivo to the diabetic environment of mice also mimic the microvascular changes found in diabetic patients. DLL4 and NOTCH3 have been identified as the leading drivers of diabetic angiopathy in human blood vessels. Therefore, human stem cell-derived organoids faithfully reproduce the structure and function of human blood vessels, modeling and identifying regulators of diabetic angiopathy.

      Reference
      Wimmer, R. A., Leopoldi, A., Aichinger, M., Wick, N., Hantusch, B., Novatchkova, M., Taubenschmid, J., Hämmerle, M., Esk, C., Bagley, J. A., Lindenhofer, D., Chen, G., Boehm, M., Agu, C. A., Yang, F., Fu, B., Zuber, J., Knoblich, J. A., Kerjaschki, D., & Penninger, J. M. (2019). Human blood vessel organoids as a model of diabetic vasculopathy. Nature, 565(7740), 505–510. https://doi.org/10.1038/s41586-018-0858-8

      • I have learned a lot of things from this article. However, I still find it confusing when it comes to the connection between the mice and diabetic patients. That is why, I had a mini-research on it and luckily, I found this. Now, if you have the same experience as I am, feel free to read this short explanation. Thank you and God Bless!

        Link: https://www.biochemed.com/news/mice-used-in-diabetes-research-everything-you-need-to-know-about-this-important-research-model/

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