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Natalie Uy posted an update in the group
MT 30 – GH (Lec) 4 years ago Hello everyone! Check out this interesting article I found on hypertension and cardiac dysfunction and its roles of immunometabolism in macrophage activation and inflammation. Have fun learning!
(PDF) Obesity, Hypertension, and Cardiac Dysfunction: Novel Roles of Immunometabolism in Macrophage Activation and InflammationPDF | Obesity and hypertension, which often coexist, are major risk factors for heart failure and are characterized by chronic, low-grade inflammation,… | Find, read and cite all the research you need on ResearchGate-
Obesity is a leading cause of hypertension and stroke that increases target-organ damage and blood pressure complications. What frequently coexist are obesity and hypertension that are key risk factors for heart failure, with persistent, low-grade inflammation promoting unfavorable cardiac remodeling. As a result, it is crucial to comprehend the factors on what causes obesity, hypertension and diabetes. A continuous entity is preferred, especially in terms of inflammation Macrophage polarization which has been known to link to metabolic switching between glycolysis and mitochondrial oxidative phosphorylation. Factors that influence macrophage metabolism could impair M1/M2 balance and worsen inflammation. In this research, the researchers explore macrophages’ traditional and unexpected proinflammatory functions in obesity-hypertension-induced heart damage, including diastolic dysfunction and calcium handling. The mechanisms through which obesity and hypertension may cause macrophage metabolic dysfunction in a synergistic manner, particularly during cardiac remodeling, are unknown. Obesity and hypertension, in accordance to their finding, cause M1 macrophage polarization through mechanisms that attack macrophage metabolism directly such as the alterations in circulating glucose and fatty acid substrates, lipotoxicity, and tissue hypoxia observed.
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