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The digestive system is composed of the gastrointestinal tract—commonly referred to as the GI tract or digestive tract—as well as the liver, pancreas, and gallbladder. The gastrointestinal system is made up of a succession of hollow organs connected by a long, twisting tube that runs from the mouth to the anus. The mouth, esophagus, stomach, small intestine, large intestine, and anus are the hollow organs that comprise the GI tract. The liver, pancreas, and gallbladder are the digestive system’s solid organs (NIDDK, 2019).
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The pancreas is the main enzyme-producing accessory gland of the digestive system.
The endocrine part of the pancreas, consists of isolated islands of lighter staining cells called islets of Langerhans. The secretions of the acini empty into ducts lined with a simple low cuboidal epithelium, which becomes stratified cuboidal in the larger ducts.
Source: https://www.histology.leeds.ac.uk/digestive/pancreas.php#:~:text=The%20endocrine%20part%20of%20the,cuboidal%20in%20the%20larger%20ducts.
The pancreas has both endocrine and exocrine functions, with the islets of Langerhans representing the endocrine portion responsible for hormone secretion like insulin and glucagon. These lighter-staining clusters are scattered among the darker-staining acinar cells, which make up the exocrine portion. The duct system, beginning with simple cuboidal epithelium and transitioning to stratified cuboidal in larger ducts, efficiently channels digestive enzymes into the duodenum.