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The digestive system is composed of the gastrointestinal tract—commonly referred to as the GI tract or digestive tract—as well as the liver, pancreas, and gallbladder. The gastrointestinal system is made up of a succession of hollow organs connected by a long, twisting tube that runs from the mouth to the anus. The mouth, esophagus, stomach, small intestine, large intestine, and anus are the hollow organs that comprise the GI tract. The liver, pancreas, and gallbladder are the digestive system’s solid organs (NIDDK, 2019).
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These distinctive differences in architecture of the epithelium can be seen below in the micrographs of digestive system. The magnification of all four images is identical and the epithelial layer is oriented toward the top.